Essays in Biochemistry Volume 50

ABC Transporters

Edited by F. J. Sharom

Since the discovery 35 years ago of P-glycoprotein, enormous progress has been made in understanding the structure, function and mechanism of action of the ABC superfamily. The present volume of Essays in Biochemistry focuses on the current state of our knowledge, and also highlights future goals and challenges. The beginning of the volume provides an introduction to the superfamily, whereas the later chapters discuss the important role that these proteins play in various organisms, and in human health and disease.

Contents

ABC transporters, mechanisms and biology: an overview
I. Barry Holland..........1
doi:10.1042/bse0500001
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Natural history of ABC systems: not only transporters
Elie Dassa..........19
doi:10.1042/bse0500019
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Structure of ABC transporters
Joseph K. Zolnerciks, Edward J. Andress, Michael Nicolaou and Kenneth J. Linton..........43
doi:10.1042/bse0500043
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Catalytic and transport cycles of ABC exporters
Marwan K. Al‑Shawi..........63
doi:10.1042/bse0500063
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ABC solute importers in bacteria
Jinming Cui and Amy L. Davidson..........85
doi:10.1042/bse0500085
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ABC proteins in yeast and fungal pathogens
Cornelia Klein, Karl Kuchler and Martin Valachovic..........101
doi:10.1042/bse0500101
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ABC transporters involved in drug resistance in human parasites
Philippe Leprohon, Danielle Légaré and Marc Ouellette..........121
doi:10.1042/bse0500121
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Functions of ABC transporters in plants
Tobias Kretzschmar, Bo Burla, Youngsook Lee, Enrico Martinoia and Réka Nagy..........145
doi:10.1042/bse0500145
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The P-glycoprotein multidrug transporter
Frances J. Sharom..........161
doi:10.1042/bse0500161
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Mammalian multidrug-resistance proteins (MRPs)
Andrew J. Slot, Steven V. Molinski and Susan P.C. Cole..........179
doi:10.1042/bse0500179
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The controversial role of ABC transporters in clinical oncology
Akina Tamaki, Caterina Ierano, Gergely Szakacs, Robert W. Robey and Susan E. Bates..........209
doi:10.1042/bse0500209
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Insights into the mechanisms underlying CFTR channel activity, the molecular basis for cystic fibrosis and strategies for therapy
Patrick Kim Chiaw, Paul D.W. Eckford and Christine E. Bear..........233
doi:10.1042/bse0500233
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The TAP translocation machinery in adaptive immunity and viral escape mechanisms
Rupert Abele and Robert Tampé..........249
doi:10.1042/bse0500249
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