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© 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).
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- Published online June 27, 2018.
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Advances in methods for reducing mitochondrial DNA disease by replacing or manipulating the mitochondrial genome
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- Article
- Abstract
- Introduction
- Preventing mtDNA transmission
- Preimplantation genetic diagnosis
- Mitochondrial donation
- Maternal spindle transfer
- Pronuclear transfer
- Approaches to shifting mtDNA heteroplasmy
- Antigenomic mtDNA therapy
- Targeted restriction endonucleases
- Zinc-finger nucleases
- Transcription activator-like effector nucleases
- CRISPR technology
- Conclusion
- Summary
- Funding
- Competing Interests
- References
- Figures
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