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Review Article

Advances in methods for reducing mitochondrial DNA disease by replacing or manipulating the mitochondrial genome

Pavandeep K. Rai, Lyndsey Craven, Kurt Hoogewijs, Oliver M. Russell, Robert N. Lightowlers
Essays In Biochemistry Jun 27, 2018, EBC20170113; DOI: 10.1042/EBC20170113
Pavandeep K. Rai
Wellcome Centre for Mitochondrial Research, Newcastle upon Tyne, U.K.
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Lyndsey Craven
Wellcome Centre for Mitochondrial Research, Newcastle upon Tyne, U.K.
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Kurt Hoogewijs
Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281 S4, 9000 Ghent, Belgium
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Oliver M. Russell
Wellcome Centre for Mitochondrial Research, Newcastle upon Tyne, U.K.
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Robert N. Lightowlers
Wellcome Centre for Mitochondrial Research, Newcastle upon Tyne, U.K.
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  • For correspondence: robert.lightowlers@ncl.ac.uk
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Article Information

DOI 
https://doi.org/10.1042/EBC20170113
PubMed 
29950320

Print ISSN 
0071-1365
Online ISSN 
1744-1358

Article Versions

  • You are currently viewing a previous version of this article (June 27, 2018 - 00:00).
  • View the most recent version of this article
Copyright & Usage 
© 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).

History 
  • Published online June 27, 2018.

Author Information

  1. Pavandeep K. Rai1,
  2. Lyndsey Craven1,
  3. Kurt Hoogewijs2,
  4. Oliver M. Russell1 and
  5. Robert N. Lightowlers1⇑
  1. 1Wellcome Centre for Mitochondrial Research, Newcastle upon Tyne, U.K.
  2. 2Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281 S4, 9000 Ghent, Belgium
  1. Correspondence:
    Robert N. Lightowlers (robert.lightowlers{at}ncl.ac.uk)
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Article usage

Article usage: June 2018 to January 2019

AbstractFullPdf
Jun 201805117
Jul 2018027796
Aug 20181339100
Sep 2018353256
Oct 2018049853
Nov 2018469247
Dec 2018059143
Jan 20191345034
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Advances in methods for reducing mitochondrial DNA disease by replacing or manipulating the mitochondrial genome
Pavandeep K. Rai, Lyndsey Craven, Kurt Hoogewijs, Oliver M. Russell, Robert N. Lightowlers
Essays In Biochemistry Jun 2018, EBC20170113; DOI: 10.1042/EBC20170113
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Advances in methods for reducing mitochondrial DNA disease by replacing or manipulating the mitochondrial genome
Pavandeep K. Rai, Lyndsey Craven, Kurt Hoogewijs, Oliver M. Russell, Robert N. Lightowlers
Essays In Biochemistry Jun 2018, EBC20170113; DOI: 10.1042/EBC20170113

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  • Article
    • Abstract
    • Introduction
    • Preventing mtDNA transmission
    • Preimplantation genetic diagnosis
    • Mitochondrial donation
    • Maternal spindle transfer
    • Pronuclear transfer
    • Approaches to shifting mtDNA heteroplasmy
    • Antigenomic mtDNA therapy
    • Targeted restriction endonucleases
    • Zinc-finger nucleases
    • Transcription activator-like effector nucleases
    • CRISPR technology
    • Conclusion
    • Summary
    • Funding
    • Competing Interests
    • References
  • Figures
  • Info & Metrics
  • PDF

Keywords

mitochondrial dysfunction
mtDNA
mitochondrial therapeuticsss

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