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Essays in Biochemistry

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  • Celebrating increasing collaboration between societies, the Biochemical Society and the British Society for Immunology have created this curated collection of articles from key topics.
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Review Articles

  • Open Access
    Measuring microtubule dynamics
    Alexander James Zwetsloot, Gokhan Tut, Anne Straube
    Essays In Biochemistry Oct 04, 2018, 62 725-735; DOI: https://doi.org/10.1042/EBC20180035
  • Open Access
    Microtubule structure by cryo-EM: snapshots of dynamic instability
    Szymon W. Manka, Carolyn A. Moores
    Essays In Biochemistry Oct 12, 2018, 62 737-751; DOI: https://doi.org/10.1042/EBC20180031
  • You have accessRestricted access
    Trafficking of ciliary membrane proteins by the intraflagellar transport/BBSome machinery
    Jenna L. Wingfield, Karl-Ferdinand Lechtreck, Esben Lorentzen
    Essays In Biochemistry Oct 04, 2018, 62 753-763; DOI: https://doi.org/10.1042/EBC20180030
  • Open Access
    Microtubule nucleation by γ-tubulin complexes and beyond
    Corinne A. Tovey, Paul T. Conduit
    Essays In Biochemistry Oct 12, 2018, 62 765-780; DOI: https://doi.org/10.1042/EBC20180028
  • Open Access
    TAPping into the treasures of tubulin using novel protein production methods
    Nuo Yu, Niels Galjart
    Essays In Biochemistry Nov 14, 2018, 62 781-792; DOI: https://doi.org/10.1042/EBC20180033
  • Open Access
    Bridging centrioles and PCM in proper space and time
    Ramya Varadarajan, Nasser M. Rusan
    Essays In Biochemistry Nov 14, 2018, 62 793-801; DOI: https://doi.org/10.1042/EBC20180036
  • You have accessRestricted access
    Context-dependent spindle pole focusing
    Lori Borgal, James G. Wakefield
    Essays In Biochemistry Nov 14, 2018, 62 803-813; DOI: https://doi.org/10.1042/EBC20180034
  • Open Access
    Composition, structure and function of the eukaryotic flagellum distal tip
    Jacob T. Croft, Davide Zabeo, Radhika Subramanian, Johanna L. Höög
    Essays In Biochemistry Nov 21, 2018, 62 815-828; DOI: https://doi.org/10.1042/EBC20180032
  • Open Access
    Coordination of eukaryotic cilia and flagella
    Kirsty Y. Wan
    Essays In Biochemistry Nov 21, 2018, 62 829-838; DOI: https://doi.org/10.1042/EBC20180029
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Essays In Biochemistry: 62 (6)
Essays In Biochemistry: 62 (5)
Essays In Biochemistry: 62 (4)
Essays In Biochemistry: 62 (3)
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The latest issue (volume 62, issue 6) deals with the topic of Microtubules and Centrosomes. The cover image shows microtubule catastrophe, the moment at which the polymer begins to fall apart by outward peeling of longitudinally connected stretches of tubulin, known as protofilaments. This mode of depolymerisation has long been observed thanks to nanometre-scale electron microscopy, but it lacked mechanistic explanation. Recent work addressed the structural basis of microtubule dynamic instability using cryo-electron microscopy (cryo-EM) at near-atomic resolution. This and other major insights into microtubule biology revealed by cryo-EM are reviewed by Manka and Moores in this issue (see pages 737-751). The atomic surface model was created in ChimeraX using experimentally determined tubulin conformations and was kindly provided by Szymon Manka (Birkbeck, University of London).

 

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