Table 1 Orthologues of proteins involved in microtubule nucleation in selected species
CategoryHomo sapiensDrosophila melanogasterArabidopsis thalianaCaenorhabditis elegansCandida albicansAspergillus nidulansSchizosaccharomyces pombeSaccharomyces cerevisiae
γ-TuSCγ-tubulinγ-tubulin 23C/37CTUBG1/2Tbg1Tub1mipATug1/Tubg1Tub4
GCP2Grip84Spc97p/GCP2Grip1/Gip1Spc97GCP2/BAlp4Spc97
GCP3Grip91Spc98p/GCP3Grip2/Gip2Spc98GCP3/CAlp6Spc98
γ-TuRC GCPsGCP4Grip75GCP4?-GCP4/DGfh1-
GCP5Grip128GCP5?-GCP5/EMod21-
GCP6Grip163GCP6?-GCP6/FAlp16-
γ-TuRC otherNEDD1/GCP-WDGrip71Nedd1?----
MOZART1Mozart1GIP1a/bMzt1Mzt1Mzt1/MztAMzt1-
MOZART2A--?----
MOZART2B
NME7Nmdyn-D7?-????
LGALS3BP???????
CM1-domain γ-TuRC tetheringCDK5RAP2, Myomegalin, PericentrinCnn, (Plp - no CM1 domain)??Spc110, Spc72PcpA, ApsBPcp1, Mto1/Mto2Spc110, Spc72
γ-TuRC- independent microtubule nucleatorschTog/CKAP5Msps?Zyg9??Alp14Stu2
TPX2Mei38Tpx2Tpxl-1----
  • The table shows orthologues of γ-TuRC proteins, CM1-domain-containing γ-TuRC tethering proteins and γ-TuRC-independent proteins involved in microtubule nucleation across a selection of species, as indicated. ‘-’ refers to cases where attempts in the literature have failed to identify an orthologue and ‘?’ refers to cases where we are unaware of any attempts to identify an orthologue. Abbreviation: CM1, centrosomin motif 1.