Table 1 Protein residents of the flagellum tip identified by immunofluorescence or immunogold labelling in various organisms
ProteinInvolved InTbCrHsMmCeDmGiTtLmXlRef.
EB1Dynamics, IFT regulationEmbedded ImageEmbedded Image[54–58]
EB3DynamicsEmbedded ImageEmbedded Image[55,59]
CDPK1IFT regulationEmbedded Image[60]
FLA8 (Kif3B)IFT regulationEmbedded Image[60]
Kif19ADynamicsEmbedded Image[61,62]
Kinesin 13DynamicsEmbedded ImageEmbedded ImageEmbedded Image[63,64,58]
Kif7Dynamics, signallingEmbedded Image[65–67]
Kif17 (OSM-3)IFT motorEmbedded Image[68]
CEP104 (CrFAP256, TbACS3)CiliogenesisEmbedded ImageEmbedded ImageEmbedded Image[25,69,70]
PRMT1DynamicsEmbedded Image[71]
PRMT3DynamicsEmbedded Image[71]
PRMT5DynamicsEmbedded Image[71]
PRMT10DynamicsEmbedded Image[71]
AgglutininTip adhesionEmbedded Image[72]
ACS1StructureEmbedded Image[70]
ACS2StructureEmbedded Image[70]
FCP1StructureEmbedded Image[70]
FCP4 (TbKin15)StructureEmbedded Image[70]
SentanStructureEmbedded ImageEmbedded Image[73]
AmoSperm activationEmbedded Image[74,75]
NOMPCSignallingEmbedded Image[76]
Gli2SignallingEmbedded Image[67,77,78]
Gli3SignallingEmbedded Image[67,77,78]
SufuSignallingEmbedded Image[65,78]
DCDC2CUnknownEmbedded Image[12]
Tb927.1.2710UnknownEmbedded Image[70]
FLAM8UnknownEmbedded Image[11]
CALP1.3UnknownEmbedded Image[79]
SKCRP7.2UnknownEmbedded Image[79]
  • Blue cross sections of a cilium indicate presence in motile cilia, green indicates presence in sensory cilia. Abbreviations: Ce, Caenorhabditis elegans; Cr, Chlamydomonas reinhardtii; Dm, Drosophila melanogaster; EB, end binding protein; Gi, Giardia intestinalis; Hs, Homo sapiens; Lm, Leishmania major; Mm, Mus musculus; Sufu, suppressor of fused; Tb, Trypanosoma brucei; Tt, Tetrahymena thermophila; Xl, Xenopus laevis.